The SQL Anywhere database server will bind listeners to all identified network IPs and there will be some overhead associated with that.
However, only this should not cause a significant change in performance
SQL Anywhere 11 or later
SAP SQL Anywhere 16.0 ; SAP SQL Anywhere 17.0 ; SAP Sybase SQL Anywhere 12.0 ; Sybase SQL Anywhere 11.0
network adapter, dbsrv, dbeng, LINK, Network interface controller, TCP/IP, HTTP, HTTPS, MyIP , KBA , BC-SYB-SQA-SRV , SQL Anywhere - Server , How To
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