2352087 - Introscope Enterprise Manager is offline due to 'No such destination of type HTTP exists' or 'EM destination IntroscopeEM_<HOST>@6001 not fully configured' errors

In the defaultTrace.rfc file of the SAP Solution Manager JAVA stack there are error messages like:

• Error accessing to Enterprise Manager: <EM_HOST>@<EM_PORT>
  [EXCEPTION] {0}#1#com.sap.smd.introscope.em.IntroscopeException: com.sap.security.core.server.destinations.api.DestinationException: [destination_0000] No such destination of type HTTP exists.
  Caused by: com.sap.security.core.server.destinations.api.DestinationException: [destination_0000] No such destination of type HTTP exists.

• Error accessing to Enterprise Manager: <EM_HOST>@<EM_PORT>
  [EXCEPTION]
  com.sap.smd.introscope.em.IntroscopeException: EM destination IntroscopeEM_<HOSTNAME>@<EM_PORT>not fully configured
  at com.sap.smd.introscope.em.rest.IntroscopeHttpConnection.executeQuery(IntroscopeHttpConnection.java:137)
  at com.sap.smd.introscope.em.PooledConnection.executeQuery(PooledConnection.java:26)
  at com.sap.sup.admin.wily.jdbc.EMInfo.queryForCollectors(EMInfo.java:233)
  at com.sap.smd.introscope.em.rest.EmRestGateway.test(EmRestGateway.java...(truncated)

• SAP Solution Manager 7.2
• Introscope EM 10.x

Interscope offline; @6001 not fully configured , KBA , SV-SMG-DIA-WLY-EMS , Enterprise Manager Setup , Problem