2550210 - DirectConnect returning this message: Description(SYBTCP_FAIL), TCP API RetCode (10060)

• Customer is seeing connection and latency issues when trying to connect to MainframeConnect(MFC) CICS listener.
• DirectConnect logs show:
  
            10/11/2017 9:59:12 AM SybMessagehandler: 30261 10 TCPIP
            Network Error: { [NOTCONNECTED] Lost connection to database,
            , Request(Connect),SubFunc(Failed), SYBTCP RetCode(1)
            Description(SYBTCP_FAIL), TCP API RetCode (10060)
            Description(WSAE TIMEDOUT) }
            <HostName=xxx.xxx.xxx.xxx>, <PortNumber=2XXXX>,
            <Region Name=CICSPROD>, <TPName=AMD2> CICSxxxx

• MainframeConnect version 15 SP 5
• DirectConnect version 15.7

OSC MFC CICS , KBA , BC-SYB-MFC , Mainframe Connect (MFC) , Problem