2751647 - No route to host error: SCC tunnel connection failed

SAP Cloud Connector (SCC) to SAP Cloud Platform (SCP) connection fails with "no route to host" error:

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#ERROR#com.sap.scc.rt#http-bio-50201-exec-2# #Tunnel Connect Failed
io.netty.channel.AbstractChannel$AnnotatedNoRouteToHostException:
No route to host:
connectivitynotification.int.sap.hana.ondemand.com/155.56.225.37:443
at java.lang.Thread.run(Thread.java:808)|
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• SAP Cloud Platform
• SAP Cloud Platform Cloud Connector
• Release Independent

Production ABAP R/3 ERP SRM CRM ERP PPM SEM APO XI PI PORTAL Test development QA KBA On Premise HANA Database SAP Cloud Platform Cloud Connector xsodata On-Premise Access Control HANA DB Cloud to On-Premise HTTPS connection ABAP com.sap.scc.rt SccEndpointValidator , KBA , BC-MID-SCC , SAP Cloud Connector On-Demand/On-Premise Connectivity , BC-NEO-CON , Neo to On-premise Connectivity service , Problem