3339291 - Profitaility Segment button disabled / greyed out for line items

When accessing the Assignment Items tab in some Controlling apps (Manage Direct Activity Allocation, Reassign Costs and Revenues...) you notice that the button "Profitability Segment" is disabled / greyed out.

 ***Image/data in this KBA is from SAP internal systems, sample data, or demo systems. Any resemblance to real data is purely coincidental.***

SAP S/4HANA Cloud

Profitability Segment, greyed out button, disabled, Reassign Costs and Revenues, Manage Direct Activity Allocation , KBA , CO-FIO-PA-2CL , Profitability Management (Public Cloud) , CO-FIO-CCA-TRA , Transactions , CO-FIO-PA , Profitability Management , CO-FIO-CCA-TRA-2CL , Transactions (Public Cloud) , How To