3376797 - "App could not be opened" error after first login, application navigation works after error message pop-up is closed

When accessing a tile after logging in for the first time, the following error messages are raised: "App could not be opened either due to an incorrect SAP Fiori launchpad configuration or a missing role assignment. Failed to resolve navigation target "#SemanticObject-action". This is most likely caused by an incorrect SAP Fiori launchpad content configuration or by a missing role assignment."

SAP S/4HANA Cloud

1. Log in to SAP S/4HANA Cloud system.
2. Once the Fiori Launchpad has loaded, click on any tile.
3. Getting error message: App could not be opened either due to an incorrect SAP Fiori launchpad configuration or a missing role assignment. Failed to resolve navigation target "#SemanticObject-action". This is most likely caused by an incorrect SAP Fiori launchpad content configuration or by a missing role assignment.
4. In the error message pop up, click on the Close button.
5. Click again on the same tile and no issue is found.

There are several causes for this error message but it has been noticed that the most common cause is that the end user is using the wrong SAP Fiori Launchpad URL https://my123546.s4hana.ondemand.com/ui#shell-home 

Semantic Objects are case sensitive.

The SAP Fiori Launchpad semantic object should be https://my123456.s4hana.ondemand.com/ui#Shell-home

first login, first time tile access, Shell-home, App could not be opened either due to an incorrect SAP Fiori launchpad configuration or a missing role assignment, Failed to resolve navigation target "#SemanticObject-action". This is most likely caused by an incorrect SAP Fiori launchpad content configuration or by a missing role assignment. , KBA , CA-FLP-FE-AI , Application iframe communication in FLP and Work Zone , Problem