3422349 - Not able to send message from Lookup call

• Issue at sending a data from lookup function.
• Soap lookup with mapping to call target system fails with a similar errors:
  

  MP: processing local module localejbs/sap.com/com.sap.aii.af.soapadapter/XISOAPAdapterBean
  Information    XISOAP: XI message received for processing
  Information    XI packaging (bulk mode) is not enabled. Switching to normal processing....
  Information    SOAP: Request message entering the adapter processing with user Guest
   Information    SOAP: Target url: http://Hostname:Port/MessagingSystem/receive/JPR/XI
  Information    Message was received by the messaging system. Protocol: XI URL: http://Hostname:Port/MessagingSystem/receive/JPR/XI Credential (User)
  1/16/2024 05:02:07.919 PM    Information    Using connection JPR. Trying to put the message into the request queue
  
  1/16/2024 05:05:07.915 PM    Error    Synchronous timeout exceeded
  1/16/2024 05:05:07.916 PM    Error    Message status set to FAIL
  1/16/2024 05:05:07.923 PM    Error    Error during parsing the received XMB message.
  1/16/2024 05:05:07.924 PM    Error    SOAP: Call failed: com.sap.aii.af.sdk.xi.srt.BubbleException: System Error Received. HTTP Status Code = 200: However System Error received in payload ErrorCode = GENERAL ErrorCategory = XIAdapterFramework Parameter1 =   Parameter2 =   Parameter3 =   Parameter4 =   Additional text = com.sap.engine.interfaces.messaging.api.exception.MessageExpiredException: Message 00000000000000(INBOUND) expired ErrorStack =   [http://sap.com/xi/XI/Message/30^Error "GENERAL"]
  Error    SOAP: Error occurred: com.sap.engine.interfaces.messaging.api.exception.MessagingException: com.sap.aii.af.sdk.xi.srt.BubbleException: System Error Received. HTTP Status Code = 200: However System Error received in payload ErrorCode = GENERAL ErrorCategory = XIAdapterFramework Parameter1 =   Parameter2 =   Parameter3 =   Parameter4 =   Additional text = com.sap.engine.interfaces.messaging.api.exception.MessageExpiredException: Message 997c0ef9-b488-11ee-97ec-00000038e9ba(INBOUND) expired ErrorStack =   [http://sap.com/xi/XI/Message/30^Error "GENERAL"]
  ErrorStack =   [http://sap.com/xi/XI/Message/30^Error "GENERAL"]
  1/16/2024 05:08:19.282 PM    Error    JPR could not process the message. Reason: Error while processing request
  1/16/2024 05:08:19.283 PM    Error    Delivery of the message to the application using connection JPR failed, due to: com.sap.engine.interfaces.messaging.api.exception.MessagingException: Error processing inbound message. Exception: Error while processing request. Setting message to status failed
  
  "Unable to open connection to host "Hostname:port". The host is down or unavailable.. " 

   

• SAP NetWeaver
• SAP Process Integration 7.50 

Process Orchestration 7.50, Process Integration 7.50, PI 7.50, PO 7.50, NetWeaver, JPR, Lookup, Java Proxy , KBA , BC-XI-CON-JPR , Java Proxy Runtime , Problem