3477415 - Intermittent “Unable to create a socket” error in SAOP Receiver Channel

The SOAP Receiver channel is intermittently failing with an "Unable to create a socket" error. Additionally, XPI Inspector traces using example 50 are displaying this error:

Error creating client SSL socket
[EXCEPTION]
java.net.ConnectException: Connection timed out: connect (local port 64240 to address X:X:X:X:X:X:X:X, remote port 443 to address XX.XXX.XX.XX)
at java.net.DualStackPlainSocketImpl.connect0(Native Method)
at java.net.DualStackPlainSocketImpl.socketConnect(DualStackPlainSocketImpl.java:75)
at java.net.AbstractPlainSocketImpl.doConnect(AbstractPlainSocketImpl.java:476)
at java.net.AbstractPlainSocketImpl.connectToAddress(AbstractPlainSocketImpl.java:218)
at java.net.AbstractPlainSocketImpl.connect(AbstractPlainSocketImpl.java:200)
at java.net.PlainSocketImpl.connect(PlainSocketImpl.java:163)
at java.net.SocksSocketImpl.connect(SocksSocketImpl.java:394)
at java.net.Socket.connect(Socket.java:874)
at java.net.Socket.connect(Socket.java:811)
at java.net.Socket.<init>(Socket.java:707)
at java.net.Socket.<init>(Socket.java:484)
at iaik.security.ssl.SSLSocket.<init>(SourceFile:108)
at com.sap.aii.af.sdk.xi.net.SSLSocketFactory.createSocket(SSLSocketFactory.java:413)
at com.sap.aii.af.sdk.xi.net.HTTPClientConnection.classicSSLConnection(HTTPClientConnection.java:1127)
at com.sap.aii.af.sdk.xi.net.HTTPClientConnection.call(HTTPClientConnection.java:567)
at com.sap.aii.af.sdk.xi.net.HTTPClientConnection.post(HTTPClientConnection.java:309)
at com.sap.aii.af.sdk.xi.srt.CallerServiceImpl2.call(CallerServiceImpl2.java:267)
at com.sap.aii.af.sdk.xi.srt.TransportBubble.onMessage(TransportBubble.java:50)

[...]

SAP NetWeaver

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, remote, DualStackPlainSocketImpl,, Native, Method, exceptions, detected, indicate, problem, side, connection, network, issue, firewall,  checks, level, blocking, communication, proxy,  , KBA , BC-XI-CON-SOP , SOAP Adapter , Problem